Endocrine Abstracts

Pregnancy in acromegalic patients is an infrequent event, but with earlier diagnosis and advanced surgical/medical management, more affected women get pregnant.The use of Somatostatin analogues (SSA) during pregnancy seems safe, but there are few reported pregnancies under this treatment.We report two acromegalic patients treated with SSA that became pregnant.Case 1: Thirty-three year old woman diagnosed with...

Introduction: The aim was to compare the incidence of type 1 diabetes between immigrant Moroccan and Romanian children and background population in Piedmont, Italy, and between Moroccan children living in Italy and their counterpart in Morocco.Patients and methods: All new cases of type 1 diabetes aged 6–13 years in Piedmont and Morocco in 2005–2009 were retrieved by regional registries. Numbers of children regularly registered to primary and m...

With the development of medical imaging, many malignant lesions of the adrenal lodge are incidentally discovered. In this prospective monocentric study we are looking for factors of presumption of malignancy in the preoperative stage on a non-oncological series of 91 IS.Monocentric prospective study, AI revealed by TDM±echo supplemented by a clinic/hormonal adrenal exploration ±isotopic. In the absence of against indications, the indication of ...

Studies showed an increase of cardiovascular risk (CVR) and reduction of the life expectancy observed in the anterior pituitary insufficiency (API) subjects. The morbimortality would be related to GH deficiency not substituted.Aim: To seek the frequency of the hypertension and analyse the predictive factors in subjects with API.A retrospective study relating 55 (47 women, eight men) subjects with API: interrupted pituitarystalk n:6...

Introduction: Testosterone therapy for hypogonadal men has been used for decades. However, there are still concerns regarding the safety of this treatment, particularly in elderly men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 66 months.<p class="abst...

The aims of the study were to analyze the relationship among insulin resistance, obesity, dysglycemia, dyslipidemia and to evaluate the role of common variants in candidate genes for their ability to predict the metabolic syndrome and cardio-metabolic risk factors.Subjects and methods: 752 non-diabetic individuals (190 males and 562 females; age 35.05+4.47 years, BMI 26.72+5.92 kg/m2) participating in the study were genotyped for variants in p...

Introduction: Obesity is associated with reduced testosterone, and low testosterone induces weight gain. This study analysed the effects of normalization of serum testosterone in mainly elderly, hypogonadal men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤ 3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 6...

We report a case of Cushing’s disease associated to nephrotic syndrome. A 21-year old female was admitted to Cittadella-Hospital due to recent occurrence of weight gain, acne, hirsutism, amenorrhea and mild hypertension. Physical examination revealed truncal obesity, moon face, buffalo hump and a bilateral ankle edema. Suspected hypercortisolism was confirmed by elevated 24 h urinary cortisol (385 μg/24 h, normal range 32–250 μg/24 h) and failure to suppres...

A 22-year old female diagnosed with thyrotoxicosis with raised free thryroxine (16.8 pmol/l) and suppressed thyroid-stimulating-hormone (TSH<0.03 mIU/l). She was started on Carbimazole 20 mg during end of August 2011. A fortnight later she presented with nausea, vomiting, fever and rigors. Her renal functions were deranged with a creatinine of 704 μmol/l, which worsened over the next 48 h. She subsequently needed renal replacement therapy with haemodialysis. She was c...

Introduction: Thyroxine is essential for growth and brain development in neonates. Early detection of hypothyroidism by measurement of free T4 (fT4) is therefore paramount. Moreover, the initial monitoring of Thyrax suppletion requires accurate fT4 measurements.Methods: In the Maasstad Hospital fT4 has been measured with the Immulite 2500 and from 2010 onward with the Dimension VISTA. Both instruments show good...